CNS and blood pressure controle


Role of brain angiotensin peptides in the regulation of sympathetic tone and blood pressure: interaction with glutamate, GABA and NO

PI: Alain Dupont
PhD student: Sofie Brouwers


There is increasing evidence that brain angiotensin peptides, glutamate, GABA and NO interact to control sympathetic tone and blood pressure and may be important in the pathogenesis of many forms of hypertension.
This project aims to improve our understanding of this central regulation of blood pressure and sympathetic tone in normotensive and spontaneous hypertensive rats. We study the interactions of the local renin-angiotensin system and different neurotransmitters such as glutamate, GABA and NO within the rostral ventrolaleral medulla (RVLM) and the paraventricular nucleus of the hypothalamus (PVN) of the brain. Blood pressure is monitored and neurotransmitters are measured in the PVN and RVLM under different conditions using microdialysis, and after local administration of several compounds interacting with different components of the renin-angiotensin system and of receptors agonists and antagonists as well as enzyme inhibitors. In addition we also aim to document the effect of brain angiotensin peptides on renal hemodynamics and of renal damage on the central control of blood pressure.


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