The main research objectives here are within the neurobiological field of Affective and Addictive Disorders, with a focus on psychiatry Imaging. The major goals are to gain more insight in the underlying mechanisms of emotional brain processes in the ‘healthy’ as well as in the ‘mentally affected’ human brain. Brain-imaging paradigms (MRI, fMRI, SPECT/PET,….) are used with or without the combination of neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS). The acquired neurobiological and neuropsychological knowledge of these combinations should not only increase our insight in the implicated neurocircuitries, but it should also result in appropriate treatment paradigms for patients suffering from Affective and Addictive Disorders.