Laura Légat


There is evidence that glutamate and gamma-aminobutyric acid (GABA) interact within different brain regions, the rostral ventrolateral medulla, paraventricular nucleus and nucleus tractus solitarii, in the central blood pressure regulation.

Angiotensin II, the most important effector within the renin-angiotensin-aldosterone system (RAAS), mediating its actions through the AT1R and AT2R. The AT2R, part of the “protective arm” of the RAAS, leads to therapeutic protective effects against myocardial and brain injury.

In this PhD research we aimed to investigate the role of AT2R within the different brain regions and their interaction with glutamate and GABA in the central regulation of blood pressure.


Research themes

CNS and Blood Pressure Controle