Lauren Deneyer


The purpose of my PhD research is to further investigate the potential of inhibition of system xc- as a therapeutic strategy in Parkinson’s disease, focusing on the neuroinflammation component of the disease. We therefore develop different dual-hit models combining peripheral inflammation with nigral proteasome inhibition and evaluate the synergy between neuroinflammation and proteasome inhibition-induced dopaminergic neurodegeneration in these models. Next, we use these models to further investigate the potential of system xc- as therapeutic target.

Research themes

Glutamate Transporters